Endocrine Abstracts

Major changes in paediatric and adult medical practice have been seen over recent decades with increased prevalence of and longevity in chronic diseases, a marked increase in organ transplantation, rapid increases in recognition of new genetic disorders associated with altered gonadal function. Along with these changes has come recognition of the pivotal importance of adolescent bone mass accrual, to decrease the impact of adult bone loss for those who have a chronic medical c...

Aim: To analyse a large series of patients with pituitary gigantism.Materials and methods: We included in this multicentre study 158 patients (129 males) with pituitary adenoma (PA) or hyperplasia and current/previous abnormal, excessively rapid growth velocity for age or a final height greater than 2 SD above normal for their population. Data of patients were systematically recorded in case report forms.Results: The...

Background: Cardiovascular disease is an important cause of morbidity/mortality in chronic GH hypersecretion.Aim: To evaluate cardiovascular system in a large series of patients with pituitary gigantism. Standard case report forms were used with height assessments related to local country norms. Results: 151pts (123 male) with GH-excess and abnormal growth velocity for age or final height >2SD over local norms had complete data on cardiac assessments...